Molly Stevens (Imperial College London)

In this talk I will discuss highlights of our nanomedicine portfolio including nanosensors for diagnosing and monitoring infectious and non-communicable diseases, and high molecular weight polymer carriers for enhanced delivery of saRNA therapeutics. I will present advances in Raman spectroscopy for high-throughput label-free characterization of single nanoparticles (SPARTA™) that allow us to integrally analyse a broad range bio-nanomaterials such as polymer particles, liposomes and extracellular vesicles without any modification. SPARTA™ has become an integral tool for the design of nanotherapeutics, with recent examples including DOPC-containing lipid nanoparticles for nucleic acid delivery and dendrimersome-based systems for controlled delivery of antibacterial drugs, and for profiling extracellular vesicles (EVs) for detection of breast cancer through a minimally invasive liquid biopsy. I will also discuss our cell interfacing nanoneedle platforms for multiplexed intracellular biosensing at sub-cellular resolution and modulation of biological processes. I will explore how these versatile technologies can be applied to transformative biomedical innovations.